Your mission
The Josep Carreras Leukaemia Research Institute (IJC) is a non-profit research institute based in Barcelona dedicated to advancing the understanding of leukemia and related disorders, in collaboration with the University of Barcelona and the Autonomous University of Barcelona. The IJC has laboratories in 5 clinical campuses: i) Hospital Clínic, ii) Hospital de Sant Pau and iii) Hospital Germans Trias Pujol iv) Hospital del Mar and v) Hospital Josep Trueta Girona. IJC serves as a collaborative center for basic researchers and physicians to work together on fundamental clinical and biological aspects of leukemia. The IJC offers an excellent work environment based on a multidisciplinary fusion of state-of-the-art ideas and facilities.
Dr. Manel Esteller is the principal investigator of the Cancer Epigenetics Group, which is involved in the analysis of the type and mechanisms of epigenetic alterations in cancer cells, including aberrant changes in DNA methylation and histone modifications in cancer, study of the epigenetics machinery and associated mutations, and finally, testing of epigenetic drugs
We are looking for a junior postdoctoral researcher in the field of Cancer Immuno-Biology to join Dr. Esteller’s Cancer Epigenetics Group. The scientist will be responsible for conducting experiments to identify and mechanisms of response and new combinatorial strategies to increase the efficacy of the HDAC6 inhibitors. The researcher will conduct drug screenings, as well as in vitro and in vivo experiments with HDAC6 inhibitors in combination with bispecific antibodies and chimeric antigen receptor (CAR) to find new combinatorial strategies. Furthermore, the scientist will perform a genome wide CRISPR screening to identify new mechanisms of response to HDAC6 inhibitors and will perform gain and loss of function approaches to validate the candidates in vitro and in vivo. In addition, he/she will perform cutting-edge transcriptomics such as single cell RNA-seq, spatial transcriptomics and methylome arrays to identify mechanisms underlying the combinatorial strategies and the candidates identified.
The scientist should be able to interpret the data, analyze and supervise students enrolled in the project.
This contract is part of the project CPP2023-010525, funded by MICIU/AEI/10.13039/501100011033 and FEDER, UE.